spectroscopic studies of inhibition of calmodulin activity by some drugs
نویسندگان
چکیده
the effect of four inhibitors on calmalulin (cum) were studied by a ftuorescence and ultraviolet techniques. four compounds in - ( 6 - aminohexyt) 5-chloro - i - napthalenesulphonamide] (w-7), 1 - [ bis - (4 - chtorophenyt) methyl] - 3 - [2, 4-dichloro - β - ( 2 , 4 - dichlorobenzyloxyl) phenethyt] imidazolium chloride (r24571), trifluoperazine (tfp) , thiodiphenylamide chloride (tdpac) showed inhibitory effect on bovine brain phosphodiesterase (pde) induced by cam. the concentration of inhibitors producing 50% inhibition of of ca 2+ / cam activity activity (ic50) and the hill coefficient were correlating closely between the methods, ki's and thermodynamic parameters for these interactions were estimated.
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عنوان ژورنال:
acta medica iranicaجلد ۳۴، شماره ۱-۲، صفحات ۲۰-۲۵
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